Structure optimization of positive allosteric modulators of GABA<sub>B</sub> receptors led to the unexpected discovery of antagonists/potential negative allosteric modulators.

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第一作者： Claudia,Mugnaini

第一单位： Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, I-53100 Siena, SI, Italy. Electronic address: claudia.mugnaini@unisi.it.

作者： Claudia,Mugnaini ^[1] ; Antonella,Brizzi ^[2] ; Rafaela,Mostallino ^[3] ; Maria Paola,Castelli ^[4] ; Federico,Corelli ^[2]

作者单位： Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, I-53100 Siena, SI, Italy. Electronic address: claudia.mugnaini@unisi.it. ^[1] Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, I-53100 Siena, SI, Italy. ^[2] Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy. ^[3] Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy; Guy Everett Laboratory, University of Cagliari, 09042 Monserrato, Italy; Center of Excellence "Neurobiology of Addiction", University of Cagliari, 09042 Monserrato, Italy. Electronic address: castelli@unica.it. ^[4]

关键词 GABA(B) agonists GABA(B) antagonists GABA(B) receptor Negative allosteric modulators Positive allosteric modulators