IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors.

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作者： Lauren,Giuffrida ^[1] ; Kevin,Sek ^[1] ; Melissa A,Henderson ^[1] ; Imran G,House ^[1] ; Junyun,Lai ^[1] ; Amanda X Y,Chen ^[1] ; Kirsten L,Todd ^[1] ; Emma V,Petley ^[1] ; Sherly,Mardiana ^[1] ; Izabela,Todorovski ^[2] ; Emily,Gruber ^[2] ; Madison J,Kelly ^[2] ; Benjamin J,Solomon ^[3] ; Stephin J,Vervoort ^[2] ; Ricky W,Johnstone ^[2] ; Ian A,Parish ^[1] ; Paul J,Neeson ^[1] ; Lev M,Kats ^[2] ; Phillip K,Darcy ^[4] ; Paul A,Beavis ^[5]

作者单位： Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia. ^[1] Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia. ^[2] Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia. ^[3] Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia; Department of Pathology, The University of Melbourne, Parkville, VIC 3010, Australia; Department of Immunology, Monash University, Clayton, VIC 3168, Australia. Electronic address: phil.darcy@petermac.org. ^[4] Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: paul.beavis@petermac.org. ^[5]

关键词 CAR T?cells IL-15 T(CM)TCF1 TCF7 anti-PD-1 cancer checkpoint blockade solid tumor