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首页> Bioorganic chemistry> Design, synthesis and antimycobacterial activity of new benzothiazinones inspired by rifampicin/rifapentine.

Design, synthesis and antimycobacterial activity of new benzothiazinones inspired by rifampicin/rifapentine.

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作者： Apeng,Wang ^[1] ; Yu,Lu ^[2] ; Kai,Lv ^[1] ; Chao,Ma ^[1] ; Shijie,Xu ^[1] ; Bin,Wang ^[2] ; Aoyu,Wang ^[3] ; Guimin,Xia ^[4] ; Mingliang,Liu ^[5]

作者单位： Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. ^[1] Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital College of Pharmacy, Medical University, Beijing 100149, China. ^[2] Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Hebei Medical University, Shijiazhuang 050017, China. ^[3] Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: xiaguimin@126.com. ^[4] Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: lmllyx@126.com. ^[5]

关键词 Antimycobacterial activity Benzothiazinones N-((methylene)amino)piperazine Synthesis

主题词投药, 口服(Administration, Oral);动物(Animals);抗菌药(Anti-Bacterial Agents);细胞增殖(Cell Proliferation);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物设计(Drug Design);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);微生物敏感性试验(Microbial Sensitivity Tests);分子结构(Molecular Structure);结核分枝杆菌(Mycobacterium tuberculosis);利福平(Rifampin);构效关系(Structure-Activity Relationship);噻嗪类(Thiazines);Vero细胞(Vero Cells)

DOI 10.1016/j.bioorg.2020.104135

PMID 32736151

发布时间 2021-03-02

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Bioorganic chemistry

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