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Gut T cell-independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells.

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第一作者： E K,Grasset

第一单位： Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. emilie.grasset@mssm.edu acerutti@imim.es.;Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, SE-171 77 Stockholm, Sweden.

作者： E K,Grasset ^[1] ; A,Chorny ^[2] ; S,Casas-Recasens ^[2] ; C,Gutzeit ^[2] ; G,Bongers ^[3] ; I,Thomsen ^[2] ; L,Chen ^[2] ; Z,He ^[2] ; D B,Matthews ^[2] ; M A,Oropallo ^[2] ; P,Veeramreddy ^[2] ; M,Uzzan ^[4] ; A,Mortha ^[5] ; J,Carrillo ^[6] ; B S,Reis ^[7] ; M,Ramanujam ^[8] ; J,Sintes ^[8] ; G,Magri ^[2] ; P J,Maglione ^[2] ; C,Cunningham-Rundles ^[9] ; R J,Bram ^[2] ; J,Faith ^[2] ; S,Mehandru ^[3] ; O,Pabst ^[10] ; A,Cerutti

作者单位： Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. emilie.grasset@mssm.edu acerutti@imim.es.;Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, SE-171 77 Stockholm, Sweden. ^[1] Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ^[2] Institute of Molecular Medicine, Aachen University, Aachen D-52074, Germany. ^[3] Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada. ^[4] Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.;IrsiCaixa, Hospital Germans Trias i Pujol, Badalona 08916, Spain. ^[5] Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA. ^[6] Immunology and Respiratory Disease Research, Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT 06877, USA. ^[7] Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona 08003, Spain. ^[8] Departments of Pediatrics and Immunology, Mayo Clinic, Rochester, MN 55905, USA. ^[9] Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. emilie.grasset@mssm.edu acerutti@imim.es.;Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona 08003, Spain.;Catalan Institute for Research and Advanced Studies (ICREA), Barcelona 08003, Spain. ^[10]

医学主题词动物(Animals);B-淋巴细胞(B-Lymphocytes);细菌(Bacteria);胃肠道(Gastrointestinal Tract);免疫, 黏膜(Immunity, Mucosal);免疫球蛋白A(Immunoglobulin A);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);RNA, 核糖体, 16S(RNA, Ribosomal, 16S);T淋巴细胞(T-Lymphocytes);跨膜激活剂与CAML交互蛋白质(Transmembrane Activator and CAML Interactor Protein)

DOI 10.1126/sciimmunol.aat7117

PMID 32737068

发布时间 2024-05-03

基金项目

K23 AI137183/AI/NIAID NIH HHS/United States P01 AI061093/AI/NIAID NIH HHS/United States R01 DK123749/DK/NIDDK NIH HHS/United States

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2020年5卷49期

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Gut T cell-independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells.

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Gut T cell-independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells.

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