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首页> International immunopharmacology> Anti-arthritis effect of berberine associated with regulating energy metabolism of macrophages through AMPK/ HIF-1α pathway.

Anti-arthritis effect of berberine associated with regulating energy metabolism of macrophages through AMPK/ HIF-1α pathway.

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作者： Yun,Yu ^[1] ; Weiwei,Cai ^[1] ; Jing,Zhou ^[1] ; Huaqiu,Lu ^[1] ; Ying,Wang ^[1] ; Yining,Song ^[1] ; Rui,He ^[1] ; Feilong,Pei ^[1] ; Xiaodie,Wang ^[1] ; Renhao,Zhang ^[1] ; Hao,Liu ^[2] ; Fang,Wei ^[3]

作者单位： School of Pharmacy, Bengbu Medical College, No.2600, Donghai Avenue, Bengbu 233000, Anhui, China. ^[1] School of Pharmacy, Bengbu Medical College, No.2600, Donghai Avenue, Bengbu 233000, Anhui, China; Anhui BBCA Pharmaceuticals Co., Ltd, No.6288, Donghai Avenue, Bengbu 233000, Anhui, China. ^[2] School of Pharmacy, Bengbu Medical College, No.2600, Donghai Avenue, Bengbu 233000, Anhui, China; Anhui BBCA Pharmaceuticals Co., Ltd, No.6288, Donghai Avenue, Bengbu 233000, Anhui, China; School of Chemistry and Chemical Engineering, Anhui University, No.3, Feixi Rode, Hefei 230039, Anhui, China. Electronic address: weifangmailbox@126.com. ^[3]

关键词 AMP-activated protein kinase Adjuvant arthritis Berberine Energy metabolism Hypoxia inducible factor 1α Macrophage polarization

主题词 AMP活化蛋白激酶类(AMP-Activated Protein Kinases);动物(Animals);踝关节(Ankle Joint);消炎药(Anti-Inflammatory Agents);关节炎, 实验性(Arthritis, Experimental);小檗碱(Berberine);细胞因子类(Cytokines);能量代谢(Energy Metabolism);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);脂多糖类(Lipopolysaccharides);巨噬细胞(Macrophages);男(雄)性(Male);大鼠, Sprague-Dawley(Rats, Sprague-Dawley)

DOI 10.1016/j.intimp.2020.106830

PMID 32738596

发布时间 2021-08-06

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International immunopharmacology

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