首页> Acta pharmacologica Sinica> Inhibition of the INa/K and the activation of peak INa contribute to the arrhythmogenic effects of aconitine and mesaconitine in guinea pigs.

Inhibition of the INa/K and the activation of peak INa contribute to the arrhythmogenic effects of aconitine and mesaconitine in guinea pigs.

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第一作者： Xiang-Chong,Wang

第一单位： Department of Pharmacology, The Key Laboratory of Pharmacology and Toxicology for New Drugs, Hebei Medical University, Shijiazhuang, 050017, China.;The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, 050017, China.;Department of Pharmacology, Hebei Key Laboratory of Chinese Medicine Research on Cardio-cerebrovascular Disease, Hebei Higher Education Institute Applied Technology Research Center on TCM Formula Preparation, Hebei University of Chinese Medicine, Shijiazhuang, 050091, China.

作者： Xiang-Chong,Wang ^[1] ; Qing-Zhong,Jia ^[2] ; Yu-Lou,Yu ^[2] ; Han-Dong,Wang ^[2] ; Hui-Cai,Guo ^[3] ; Xin-di,Ma ^[2] ; Chun-Tong,Liu ^[2] ; Xue-Yan,Chen ^[2] ; Qing-Feng,Miao ^[2] ; Bing-Cai,Guan ^[2] ; Su-Wen,Su ^[4] ; He-Ming,Wei ^[5] ; Chuan,Wang ^[6]

作者单位： Department of Pharmacology, The Key Laboratory of Pharmacology and Toxicology for New Drugs, Hebei Medical University, Shijiazhuang, 050017, China.;The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, 050017, China.;Department of Pharmacology, Hebei Key Laboratory of Chinese Medicine Research on Cardio-cerebrovascular Disease, Hebei Higher Education Institute Applied Technology Research Center on TCM Formula Preparation, Hebei University of Chinese Medicine, Shijiazhuang, 050091, China. ^[1] Department of Pharmacology, The Key Laboratory of Pharmacology and Toxicology for New Drugs, Hebei Medical University, Shijiazhuang, 050017, China.;The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, 050017, China. ^[2] Depatment of Toxicology, Hebei Medical University, Shijiazhuang, 050017, China. ^[3] Department of Pharmacology, The Key Laboratory of Pharmacology and Toxicology for New Drugs, Hebei Medical University, Shijiazhuang, 050017, China. suswmk@hebmu.edu.cn.;The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, 050017, China. suswmk@hebmu.edu.cn. ^[4] Research Laboratory, KK Women's & Children's Hospital, Singapore, 229899, Singapore. wei.heming@kkh.com.sg. ^[5] Department of Pharmacology, The Key Laboratory of Pharmacology and Toxicology for New Drugs, Hebei Medical University, Shijiazhuang, 050017, China. wangchuan@hebmu.edu.cn.;The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, 050017, China. wangchuan@hebmu.edu.cn. ^[6]

关键词 Na+/K+ pump current aconitine action potential arrhythmia mesaconitine voltage-gated sodium channel current