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Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda.

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第一作者： Aline,Uwimana

第一单位： Malaria and Other Parasitic Diseases Division, Rwanda Biomedical Centre (RBC), Kigali, Rwanda. Aline.Uwimana@rbc.gov.rw.

作者： Aline,Uwimana ^[1] ; Eric,Legrand ^[2] ; Barbara H,Stokes ^[3] ; Jean-Louis Mangala,Ndikumana ^[4] ; Marian,Warsame ^[5] ; Noella,Umulisa ^[6] ; Daniel,Ngamije ^[7] ; Tharcisse,Munyaneza ^[8] ; Jean-Baptiste,Mazarati ^[8] ; Kaendi,Munguti ^[9] ; Pascal,Campagne ^[10] ; Alexis,Criscuolo ^[10] ; Frédéric,Ariey ^[11] ; Monique,Murindahabi ^[12] ; Pascal,Ringwald ^[13] ; David A,Fidock ^[14] ; Aimable,Mbituyumuremyi ^[4] ; Didier,Menard ^[15]

作者单位： Malaria and Other Parasitic Diseases Division, Rwanda Biomedical Centre (RBC), Kigali, Rwanda. Aline.Uwimana@rbc.gov.rw. ^[1] Malaria Genetics and Resistance Unit-Institut Pasteur, INSERM U1201, CNRS ERL9195, Paris, France. ^[2] Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, USA. ^[3] Malaria and Other Parasitic Diseases Division, Rwanda Biomedical Centre (RBC), Kigali, Rwanda. ^[4] University of Gothenburg, Gothenburg, Sweden. ^[5] Maternal and Child Survival Program/JHPIEGO, Baltimore, MD, USA.;Impact Malaria Rwanda, Kigali, Rwanda. ^[6] Ministry of Health, Kigali, Rwanda. ^[7] National Reference Laboratory (NRL), BIOS /Rwanda Biomedical Centre (RBC), Kigali, Rwanda. ^[8] US President's Malaria Initiative, Kigali, Rwanda. ^[9] Hub de Bioinformatique et Biostatistique-Département Biologie Computationnelle, Paris, France. ^[10] INSERM 1016, Institut Cochin, Service de Parasitologie-Mycologie, Hôpital Cochin, Université de Paris, Paris, France. ^[11] Roll Back Malaria for West and Central Africa, Kigali, Rwanda. ^[12] Global Malaria Programme, World Health Organization, Geneva, Switzerland. ^[13] Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, USA.;Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. ^[14] Malaria Genetics and Resistance Unit-Institut Pasteur, INSERM U1201, CNRS ERL9195, Paris, France. dmenard@pasteur.fr. ^[15]