Naturally occurring SARS-CoV-2 gene deletions close to the spike S1/S2 cleavage site in the viral quasispecies of COVID19 patients.

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作者： Cristina,Andrés ^[1] ; Damir,Garcia-Cehic ^[2] ; Josep,Gregori ^[3] ; Maria,Piñana ^[3] ; Francisco,Rodriguez-Frias ^[4] ; Mercedes,Guerrero-Murillo ^[1] ; Juliana,Esperalba ^[3] ; Ariadna,Rando ^[5] ; Lidia,Goterris ^[6] ; Maria Gema,Codina ^[2] ; Susanna,Quer ^[1] ; Maria Carmen,Martín ^[7] ; Magda,Campins ^[7] ; Ricard,Ferrer ^[7] ; Benito,Almirante ^[2] ; Juan Ignacio,Esteban ^[1] ; Tomás,Pumarola ^[8] ; Andrés,Antón ^[9] ; Josep,Quer ^[10]

作者单位： Respiratory Viruses Unit, Microbiology Department, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain. ^[1] Liver Unit, Liver Diseases - Viral Hepatitis, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain. ^[2] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain. ^[3] Roche Diagnostics SL, Sant Cugat del Valles, Barcelona, Spain. ^[4] Biochemistry and Microbiology Departments, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain. ^[5] Universitat Autònoma de Barcelona, Bellaterra, Spain. ^[6] Microbiology Department, Vall d'Hebron Hospital Universitari, Barcelona, Spain. ^[7] Preventive Medicine, Hospital Vall d'Hebron Hospital Universitari, Barcelona, Spain. ^[8] Intensive Care Department. Shock, Disfunció Orgànica i Ressuscitació (SODIR) Research Group, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain. ^[9] Infectious Diseases Department. Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain. ^[10]

关键词 NGS SARS-CoV-2 deletions diversity quasispecies respiratory virus