A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq.

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第一作者： Angela C,Boroughs

第一单位： Cellular Immunotherapy Program and Cancer Center, Massachusetts General Hospital, Charlestown, MA 02129, USA; Harvard Medical School, Boston, MA 02115, USA.

作者： Angela C,Boroughs ^[1] ; Rebecca C,Larson ^[1] ; Nemanja D,Marjanovic ^[2] ; Kirk,Gosik ^[2] ; Ana P,Castano ^[3] ; Caroline B M,Porter ^[2] ; Selena J,Lorrey ^[3] ; Orr,Ashenberg ^[2] ; Livnat,Jerby ^[2] ; Matan,Hofree ^[2] ; Gabriela,Smith-Rosario ^[2] ; Robert,Morris ^[4] ; Joshua,Gould ^[2] ; Lauren S,Riley ^[3] ; Trisha R,Berger ^[3] ; Samantha J,Riesenfeld ^[2] ; Orit,Rozenblatt-Rosen ^[2] ; Bryan D,Choi ^[3] ; Aviv,Regev ^[5] ; Marcela V,Maus ^[6]

作者单位： Cellular Immunotherapy Program and Cancer Center, Massachusetts General Hospital, Charlestown, MA 02129, USA; Harvard Medical School, Boston, MA 02115, USA. ^[1] Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA. ^[2] Cellular Immunotherapy Program and Cancer Center, Massachusetts General Hospital, Charlestown, MA 02129, USA. ^[3] Howard Hughes Medical Institute, Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02140, USA. ^[4] Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02140, USA. Electronic address: aregev@broadinstitute.org. ^[5] Cellular Immunotherapy Program and Cancer Center, Massachusetts General Hospital, Charlestown, MA 02129, USA; Harvard Medical School, Boston, MA 02115, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: mvmaus@mgh.harvard.edu. ^[6]

关键词 CAR T?cells T cell activation adoptive cellular therapy single-cell RNA sequencing transcriptional profiling