首页> The EMBO journal> TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.

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第一作者： Ramanath Narayana,Hegde

第一单位： Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

作者： Ramanath Narayana,Hegde ^[1] ; Anass,Chiki ^[1] ; Lara,Petricca ^[2] ; Paola,Martufi ^[2] ; Nicolas,Arbez ^[3] ; Laurent,Mouchiroud ^[4] ; Johan,Auwerx ^[4] ; Christian,Landles ^[5] ; Gillian P,Bates ^[5] ; Malvindar K,Singh-Bains ^[6] ; Mike,Dragunow ^[7] ; Maurice A,Curtis ^[6] ; Richard Lm,Faull ^[6] ; Christopher A,Ross ^[3] ; Andrea,Caricasole ^[2] ; Hilal A,Lashuel ^[1]

作者单位： Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. ^[1] Department of Neuroscience, IRBM Science Park, Rome, Italy. ^[2] Division of Neurobiology, Department of Psychiatry and Departments of Neurology, Neuroscience and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ^[3] Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. ^[4] Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London, UK. ^[5] Centre for Brain Research, Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand. ^[6] Centre for Brain Research, Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand. ^[7]

关键词 Huntington's disease TBK1 autophagy huntingtin phosphorylation reducing aggregation