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Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk.

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第一作者: Minta,Thomas
第一单位: Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
作者: Minta,Thomas [1] ; Lori C,Sakoda [2] ; Michael,Hoffmeister [3] ; Elisabeth A,Rosenthal [4] ; Jeffrey K,Lee [5] ; Franzel J B,van Duijnhoven [6] ; Elizabeth A,Platz [7] ; Anna H,Wu [8] ; Christopher H,Dampier [9] ; Albert,de la Chapelle [10] ; Alicja,Wolk [11] ; Amit D,Joshi [12] ; Andrea,Burnett-Hartman [13] ; Andrea,Gsur [14] ; Annika,Lindblom [15] ; Antoni,Castells [16] ; Aung Ko,Win [17] ; Bahram,Namjou [18] ; Bethany,Van Guelpen [19] ; Catherine M,Tangen [20] ; Qianchuan,He [1] ; Christopher I,Li [1] ; Clemens,Schafmayer [21] ; Corinne E,Joshu [7] ; Cornelia M,Ulrich [22] ; D Timothy,Bishop [23] ; Daniel D,Buchanan [24] ; Daniel,Schaid [25] ; David A,Drew [26] ; David C,Muller [27] ; David,Duggan [28] ; David R,Crosslin [29] ; Demetrius,Albanes [30] ; Edward L,Giovannucci [31] ; Eric,Larson [32] ; Flora,Qu [1] ; Frank,Mentch [33] ; Graham G,Giles [34] ; Hakon,Hakonarson [33] ; Heather,Hampel [35] ; Ian B,Stanaway [4] ; Jane C,Figueiredo [36] ; Jeroen R,Huyghe [1] ; Jessica,Minnier [37] ; Jenny,Chang-Claude [38] ; Jochen,Hampe [39] ; John B,Harley [18] ; Kala,Visvanathan [7] ; Keith R,Curtis [1] ; Kenneth,Offit [40] ; Li,Li [41] ; Loic,Le Marchand [42] ; Ludmila,Vodickova [43] ; Marc J,Gunter [44] ; Mark A,Jenkins [17] ; Martha L,Slattery [45] ; Mathieu,Lemire [46] ; Michael O,Woods [47] ; Mingyang,Song [48] ; Neil,Murphy [44] ; Noralane M,Lindor [49] ; Ozan,Dikilitas [50] ; Paul D P,Pharoah [51] ; Peter T,Campbell [52] ; Polly A,Newcomb [53] ; Roger L,Milne [34] ; Robert J,MacInnis [54] ; Sergi,Castellví-Bel [16] ; Shuji,Ogino [55] ; Sonja I,Berndt [30] ; Stéphane,Bézieau [56] ; Stephen N,Thibodeau [57] ; Steven J,Gallinger [58] ; Syed H,Zaidi [59] ; Tabitha A,Harrison [1] ; Temitope O,Keku [60] ; Thomas J,Hudson [59] ; Veronika,Vymetalkova [43] ; Victor,Moreno [61] ; Vicente,Martín [62] ; Volker,Arndt [3] ; Wei-Qi,Wei [63] ; Wendy,Chung [64] ; Yu-Ru,Su [1] ; Richard B,Hayes [65] ; Emily,White [66] ; Pavel,Vodicka [43] ; Graham,Casey [67] ; Stephen B,Gruber [68] ; Robert E,Schoen [69] ; Andrew T,Chan [70] ; John D,Potter [71] ; Hermann,Brenner [72] ; Gail P,Jarvik [73] ; Douglas A,Corley [5] ; Ulrike,Peters [74] ; Li,Hsu [75]
作者单位: Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. [1] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA. [2] Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. [3] Department of Medicine (Medical Genetics), University of Washington Medical Center, Seattle, WA 98195, USA. [4] Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA. [5] Division of Human Nutrition and Health, Wageningen University & Research, Wageningen 176700, the Netherlands. [6] Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA. [7] University of Southern California, Preventative Medicine, Los Angeles, CA 90089, USA. [8] Department of Surgery, University of Virginia Health System, Charlottesville, VA 22903, USA. [9] Department of Cancer Biology and Genetics and the Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA. [10] Institute of Environmental Medicine, Karolinska Institutet, Stockholm 17177, Sweden. [11] Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. [12] Institute for Health Research, Kaiser Permanente Colorado, Denver, CO 80014, USA. [13] Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna 1090, Austria. [14] Department of Clinical Genetics, Karolinska University Hospital, Stockholm 17177, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17177, Sweden. [15] Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona 08007, Spain. [16] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3000, Australia. [17] Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Cincinnati VA Medical Center, Cincinnati, OH 45229, USA. [18] Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå 90187, Sweden; Wallenberg Centre for Molecular Medicine, Umeå University, Umeå 90187, Sweden. [19] SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. [20] Department of General Surgery, University Hospital Rostock, Rostock 18051, Germany. [21] Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT 84112, USA. [22] Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS2 9JT, UK. [23] University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC 3010, Australia; Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC 3010, Australia; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, VIC 3010, Australia. [24] Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA. [25] Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. [26] School of Public Health, Imperial College London, London SW7 2AZ, UK. [27] Translational Genomics Research Institute - An Affiliate of City of Hope, Phoenix, AZ 85003, USA. [28] Department of Bioinformatics and Medical Education, University of Washington Medical Center, Seattle, WA 98195, USA. [29] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. [30] Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02108, USA. [31] Kaiser Permanente Washington Research Institute, Seattle, WA 98101, USA. [32] Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. [33] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3000, Australia; Cancer Epidemiology Division, Cancer Council Victoria, 615 St Kilda Road, Melbourne, VIC 3004, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC 3168, Australia. [34] Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA. [35] Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. [36] School of Public Health, Oregon Health & Science University, Portland, OR 97239, USA. [37] Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69120 Germany; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg 20246, Germany. [38] Department of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden 01062, Germany. [39] Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA; Department of Medicine, Weill Cornell Medical College, NY 10065, USA. [40] Department of Family Medicine, University of Virginia, Charlottesville, VA 22903, USA. [41] University of Hawaii Cancer Center, Honolulu, HI 96813, USA. [42] Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, 142 20 Prague 4, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, 323 00 Pilsen, Czech Republic. [43] Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon 69372, France. [44] Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA. [45] PanCuRx Translational Research Initiative, Ontario, Institute for Cancer Research, Toronto, ON M5G0A3, Canada. [46] Memorial University of Newfoundland, Discipline of Genetics, St. John's, NL A1B 3R7, Canada. [47] Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02141, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA. [48] Department of Health Science Research, Mayo Clinic, Scottsdale, AZ 85260, USA. [49] Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA. [50] Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0SR, UK. [51] Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA 30303, USA. [52] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; School of Public Health, University of Washington, Seattle, WA 98195, USA. [53] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3000, Australia; Cancer Epidemiology Division, Cancer Council Victoria, 615 St Kilda Road, Melbourne, VIC 3004, Australia. [54] Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02141, USA; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. [55] Service de Génétique Médicale, Centre Hospitalier Universitaire (CHU) Nantes, Nantes 44093, France. [56] Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 85054, USA. [57] Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON M5G1X5, Canada. [58] Ontario Institute for Cancer Research, Toronto, ON M5G0A3, Canada. [59] Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC 27599, USA. [60] Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona 08908, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid 28029, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona 08907, Spain; ONCOBEL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona 08908, Spain. [61] CIBER Epidemiología y Salud Pública (CIBERESP), Madrid 28029, Spain; Biomedicine Institute (IBIOMED), University of León, León 24071, Spain. [62] Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37232, USA. [63] Office of Research & Development, Department of Veterans Affairs, Washington, DC 20420, USA; Departments of Pediatrics and Medicine, Columbia University Medical Center, New York, NY 10032, USA. [64] Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, NY 10016, USA. [65] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA. [66] Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22903, USA. [67] Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. [68] Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA 15219, USA. [69] Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02141, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA. [70] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Centre for Public Health Research, Massey University, Wellington 6140, New Zealand. [71] Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg 69120, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. [72] Department of Medicine (Medical Genetics), University of Washington Medical Center, Seattle, WA 98195, USA; Genome Sciences, University of Washington Medical Center, Seattle, WA 98195, USA. [73] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA. Electronic address: upeters@fredhutch.org. [74] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA. Electronic address: lih@fredhutch.org. [75]
DOI 10.1016/j.ajhg.2020.07.006
PMID 32758450
发布时间 2026-04-15
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American journal of human genetics

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