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Olaparib and durvalumab in patients with germline BRCA-mutated metastatic breast cancer (MEDIOLA): an open-label, multicentre, phase 1/2, basket study.

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第一作者： Susan M,Domchek

第一单位： Basser Center for BRCA, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: susan.domchek@pennmedicine.upenn.edu.

作者： Susan M,Domchek ^[1] ; Sophie,Postel-Vinay ^[2] ; Seock-Ah,Im ^[3] ; Yeon Hee,Park ^[4] ; Jean-Pierre,Delord ^[5] ; Antoine,Italiano ^[6] ; Jerome,Alexandre ^[7] ; Benoit,You ^[8] ; Sara,Bastian ^[9] ; Matthew G,Krebs ^[10] ; Ding,Wang ^[11] ; Saiama N,Waqar ^[12] ; Mark,Lanasa ^[13] ; Joon,Rhee ^[13] ; Haiyan,Gao ^[14] ; Vidalba,Rocher-Ros ^[14] ; Emma V,Jones ^[14] ; Sakshi,Gulati ^[14] ; Anna,Coenen-Stass ^[14] ; Iwanka,Kozarewa ^[14] ; Zhongwu,Lai ^[13] ; Helen K,Angell ^[14] ; Laura,Opincar ^[13] ; Pia,Herbolsheimer ^[13] ; Bella,Kaufman ^[15]

作者单位： Basser Center for BRCA, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: susan.domchek@pennmedicine.upenn.edu. ^[1] ATIP -Avenir group, Inserm Unit U981, Villejuif, France; Faculté de Médicine, Le Kremlin Bicêtre, Université Paris Saclay, Université Paris-Sud, Villejuif, France; Department of Drug Development, Gustave Roussy, Villejuif, France. ^[2] Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of South Korea. ^[3] Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of South Korea. ^[4] Institut Universitaire du Cancer de Toulouse, Toulouse, France. ^[5] Institut Bergonié, Bordeaux, France. ^[6] Hôpital Cochin, Paris, France. ^[7] Medical Oncology, Institut de Cancérologie des Hospices Civils de Lyon, Centre d'Investigation de Therapeutiques en Oncologie et H ematologie de Lyon, Centre Hospitalier Lyon-Sud, Lyon, France; Faculté de Médecine Lyon-Sud, Univ Lyon, Université Claude Bernard Lyon 1, EMR UCBL/HCL 3738, Lyon, France; Groupe des Investigateurs Nationaux pour les Cancers de l Ovaire et du sein-GINEGEPS, Paris, France. ^[8] Kantonsspital Graubuenden, Chur, Switzerland. ^[9] Division of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester and The Christie NHS Foundation Trust, Manchester, UK; Manchester Academic Health Science Centre, Manchester, UK. ^[10] Henry Ford Medical Center, Detroit, MI, USA. ^[11] Washington University School of Medicine, Saint Louis, MO, USA. ^[12] AstraZeneca, Gaithersburg, MD, USA. ^[13] AstraZeneca, Cambridge, UK. ^[14] Chaim Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. ^[15]