Introducing an In Vitro Liver Stability Assay Capable of Predicting the In Vivo Pharmacodynamic Efficacy of siRNAs for IVIVC.

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作者： Babak,Basiri ^[1] ; Fang,Xie ^[2] ; Bin,Wu ^[3] ; Sara C,Humphreys ^[2] ; Julie M,Lade ^[2] ; Mai B,Thayer ^[2] ; Pam,Yamaguchi ^[4] ; Monica,Florio ^[4] ; Brooke M,Rock ^[2]

作者单位： Amgen Research, Pharmacokinetics and Drug Metabolism, 1120 Veterans Blvd., South San Francisco, CA 94080, USA. Electronic address: bbasiri@amgen.com. ^[1] Amgen Research, Pharmacokinetics and Drug Metabolism, 1120 Veterans Blvd., South San Francisco, CA 94080, USA. ^[2] Amgen Research, Hybrid Modality Engineering, One Amgen Center Drive, Thousand Oaks, CA 91320, USA. ^[3] Amgen Research, Cardiometabolic Disorders, One Amgen Center Drive, Thousand Oaks, CA 91320, USA. ^[4]

关键词 GalNAc-conjugated siRNA IVIVC In?vitro in?vivo correlation LC-MS in?vitro metabolism liver homogenate stability mass spectrometry metabolite identification oligonucleotide metabolite identification siRNA

DOI 10.1016/j.omtn.2020.07.012

PMID 32771924

发布时间 2021-01-10

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Molecular therapy. Nucleic acids

2020年21卷

725-736页

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Introducing an In Vitro Liver Stability Assay Capable of Predicting the In Vivo Pharmacodynamic Efficacy of siRNAs for IVIVC.

Molecular therapy. Nucleic acids

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Molecular therapy. Nucleic acids

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Introducing an In Vitro Liver Stability Assay Capable of Predicting the In Vivo Pharmacodynamic Efficacy of siRNAs for IVIVC.

Molecular therapy. Nucleic acids

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Molecular therapy. Nucleic acids

相关期刊

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