Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice.

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第一作者： Mathilde R,Rivaud

第一单位： Department of Clinical and Experimental Cardiology, Amsterdam UMC, Heart Center, Academic Medical Center, Room K2-104.2, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.

作者： Mathilde R,Rivaud ^[1] ; Gerard A,Marchal ^[1] ; Rianne,Wolswinkel ^[1] ; John A,Jansen ^[2] ; Ingeborg,van der Made ^[1] ; Leander,Beekman ^[1] ; Adrián,Ruiz-Villalba ^[3] ; Antonius,Baartscheer ^[4] ; Sridharan,Rajamani ^[1] ; Luiz,Belardinelli ^[5] ; Toon A B,van Veen ^[6] ; Cristina,Basso ^[5] ; Gaetano,Thiene ^[7] ; Esther E,Creemers ^[2] ; Connie R,Bezzina ^[8] ; Carol Ann,Remme ^[8]

作者单位： Department of Clinical and Experimental Cardiology, Amsterdam UMC, Heart Center, Academic Medical Center, Room K2-104.2, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands. ^[1] Department of Medical Physiology, University Medical Center, Utrecht, The Netherlands. ^[2] Department of Anatomy, Embryology & Physiology, Amsterdam UMC, Academic Medical Center, Amsterdam, The Netherlands. ^[3] Regenerative Medicine Program, Center for Applied Medical Research (CIMA), University of Navarra, IdiSNA, Pamplona, 31008, Spain. ^[4] Department of Biological Sciences, Gilead Sciences, Foster City, USA. ^[5] Department of Cardiometabolic Disorders, Amgen Inc, 1120 Veterans Blvd, South San Francisco, CA 94080, USA. ^[6] InCarda Therapeutics Inc, 150 Northhill Drive, Brisbane, CA 94005, USA. ^[7] Department of Cardiac, Thoracic and Vascular Sciences, Cardiovascular Pathology, University of Padua, Italy. ^[8]

关键词 Atrio-ventricular block/conductionSCN5A Calcium homeostasis Late sodium current NaV1.5 ?mutations

主题词动物(Animals);钙(Calcium);人类(Humans);QT延长综合征(Long QT Syndrome);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);钠(Sodium)

DOI 10.1093/europace/euaa127

PMID 32778883

发布时间 2021-06-23

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