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首页> Comparative biochemistry and physiology. Toxicology & pharmacology : CBP> Higher intestinal and circulatory lactate associated NOX2 activation leads to an ectopic fibrotic pathology following microcystin co-exposure in murine fatty liver disease.

Higher intestinal and circulatory lactate associated NOX2 activation leads to an ectopic fibrotic pathology following microcystin co-exposure in murine fatty liver disease.

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作者： Sutapa,Sarkar ^[1] ; Punnag,Saha ^[1] ; Ratanesh K,Seth ^[1] ; Ayan,Mondal ^[1] ; Dipro,Bose ^[1] ; Diana,Kimono ^[1] ; Muayad,Albadrani ^[1] ; Avik,Mukherjee ^[2] ; Dwayne E,Porter ^[3] ; Geoff I,Scott ^[3] ; Shuo,Xiao ^[3] ; Bryan,Brooks ^[4] ; John,Ferry ^[5] ; Mitzi,Nagarkatti ^[6] ; Prakash,Nagarkatti ^[6] ; Saurabh,Chatterjee ^[7]

作者单位： Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, University of South Carolina, USA. ^[1] Hunt Optics and Imaging Inc, USA. ^[2] NIEHS Center for Oceans and Human Health on Climate Change Interactions, Department of Environmental Health Sciences, University of South Carolina, USA. ^[3] Department of Environmental Science, Baylor University, USA. ^[4] Department of Chemistry and Biochemistry, University of South Carolina, USA. ^[5] Pathology, Microbiology and Immunology(,) University of South Carolina School of Medicine, USA. ^[6] Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, University of South Carolina, USA. Electronic address: schatt@mailbox.sc.edu. ^[7]

关键词 Dysbiosis Fibrosis Lactate MC-LR NAFLD NOX2 PP2A inhibitor Peroxynitrite

主题词动物(Animals);细胞系(Cell Line);酶抑制剂(Enzyme Inhibitors);纤维化(Fibrosis);肠黏膜(Intestinal Mucosa);肠(Intestines);乳酸(Lactic Acid);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);微囊藻毒素类(Microcystins);磷酰化(Phosphorylation)

DOI 10.1016/j.cbpc.2020.108854

PMID 32781293

发布时间 2024-09-22

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Comparative biochemistry and physiology. Toxicology & pharmacology

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