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首页> Marine drugs> Chemistry of Renieramycins. Part 19: Semi-Syntheses of 22-<i>O</i>-Amino Ester and Hydroquinone 5-<i>O</i>-Amino Ester Derivatives of Renieramycin M and Their Cytotoxicity against Non-Small-Cell Lung Cancer Cell Lines.

Chemistry of Renieramycins. Part 19: Semi-Syntheses of 22-<i>O</i>-Amino Ester and Hydroquinone 5-<i>O</i>-Amino Ester Derivatives of Renieramycin M and Their Cytotoxicity against Non-Small-Cell Lung Cancer Cell Lines.

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作者： Supakarn,Chamni ^[1] ; Natchanun,Sirimangkalakitti ^[2] ; Pithi,Chanvorachote ^[3] ; Khanit,Suwanborirux ^[4] ; Naoki,Saito ^[2]

作者单位： Natural Products and Nanoparticles Research Unit (NP2), Chulalongkorn University, Bangkok 10330, Thailand. ^[1] Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand. ^[2] Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan. ^[3] Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand. ^[4]

关键词 22-O-amino ester derivatives of renieramycin M bistetrahydroisoquinolinequinone chemical modification cytotoxicity hydroquinone 5-O-amino ester derivatives of renieramycin M marine alkaloid non-small-cell lung cancer renieramycin M semi-synthesis

主题词抗肿瘤药(Antineoplastic Agents);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);细胞存活(Cell Survival);剂量效应关系, 药物(Dose-Response Relationship, Drug);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);肺肿瘤(Lung Neoplasms);分子结构(Molecular Structure);构效关系(Structure-Activity Relationship);四氢异喹啉类(Tetrahydroisoquinolines)

DOI 10.3390/md18080418

PMID 32785022

发布时间 2021-05-11

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