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首页> Thrombosis research> Predicting the metabolic characteristics of neorudin, a novel anticoagulant fusion protein, in patients with deep vein thrombosis.

Predicting the metabolic characteristics of neorudin, a novel anticoagulant fusion protein, in patients with deep vein thrombosis.

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作者： Xiaona,Dong ^[1] ; Zhiyun,Meng ^[2] ; Ruolan,Gu ^[3] ; Xiaoxia,Zhu ^[3] ; Hui,Gan ^[3] ; Jide,Jin ^[4] ; Jianglin,Liu ^[5] ; Guifang,Dou ^[6]

作者单位： Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China. Electronic address: dongxiaona@bjmu.edu.cn. ^[1] Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, China. Electronic address: mengzhiyun@vip.163.com. ^[2] Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, China. ^[3] Laboratory of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing, China. ^[4] Beijing SUYA Pharmaceutical Lab, INC, Beijing, China. ^[5] Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, China. Electronic address: douguifang@vip.163.com. ^[6]

关键词 Deep vein thrombosis Hirudin variant 2-Lys47 Metabolism Neorudin Prodrug Targeting release

主题词动物(Animals);抗凝药(Anticoagulants);水蛭素类(Hirudins);人类(Humans);大鼠(Rats);重组蛋白质类(Recombinant Proteins);血栓形成(Thrombosis);静脉血栓形成(Venous Thrombosis)

DOI 10.1016/j.thromres.2020.05.048

PMID 32788104

发布时间 2021-06-17

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