Guanosine Neuroprotection of Presynaptic Mitochondrial Calcium Homeostasis in a Mouse Study with Amyloid-β Oligomers.

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作者： Jussemara Souza,da Silva ^[1] ; Yasmine,Nonose ^[1] ; Francieli,Rohden ^[1] ; Pâmela C,Lukasewicz Ferreira ^[1] ; Fernanda Urruth,Fontella ^[1] ; Andréia,Rocha ^[1] ; Andressa Wigner,Brochier ^[1] ; Rodrigo Vieira,Apel ^[1] ; Thais Martins,de Lima ^[1] ; Bianca,Seminotti ^[1] ; Alexandre Umpierrez,Amaral ^[1] ; Antonio,Galina ^[2] ; Diogo O,Souza ^[3]

作者单位： Graduate Program in Biological Sciences - Biochemistry. Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul - UFRGS, Porto Alegre, Brazil. ^[1] Department of Biological Sciences, Integrated Regional University of High Uruguay and Missions - URI, Erechim, Brazil. ^[2] Laboratory of Bioenergetics and Mitochondrial Physiology. Graduate Program in Cellular Biophysics and Biochemistry. Institute of Medical Biochemistry Leopoldo de Meis, Health Sciences Centre, Federal University of Rio de Janeiro - UFRJ, Rio de Janeiro, Brazil. ^[3] Graduate Program in Biological Sciences - Biochemistry. Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul - UFRGS, Porto Alegre, Brazil. diogo.bioq@gmail.com. ^[4]

关键词 Alzheimer’s disease Amyloid-β oligomers Guanosine Neuroprotection Presynaptic mitochondria