ZYBT1, a potent, irreversible Bruton's Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer.

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作者： Krishnarup,Ghoshdastidar ^[1] ; Hoshang,Patel ^[1] ; Hitesh,Bhayani ^[1] ; Ankit,Patel ^[1] ; Kinjal,Thakkar ^[1] ; Dinesh,Patel ^[2] ; Manoranjan,Sharma ^[2] ; Jaideep,Singh ^[2] ; Jogeswar,Mohapatra ^[2] ; Abhijit,Chatterjee ^[2] ; Dipam,Patel ^[3] ; Rajesh,Bahekar ^[3] ; Rajiv,Sharma ^[3] ; Lakshmikant,Gupta ^[4] ; Nirmal,Patel ^[4] ; Poonam,Giri ^[4] ; Nuggehally R,Srinivas ^[4] ; Mukul,Jain ^[5] ; Debdutta,Bandyopadhyay ^[1] ; Pankaj R,Patel ^[6] ; Ranjit C,Desai ^[3]

作者单位： Department of Cell Biology, Zydus Research Center, Ahmedabad, Gujarat, India. ^[1] Department of Pharmacology, Zydus Research Center, Ahmedabad, Gujarat, India. ^[2] Department of Medicinal Chemistry, Zydus Research Center, Ahmedabad, Gujarat, India. ^[3] Department of Pharmacokinetics, Zydus Research Center, Ahmedabad, Gujarat, India. ^[4] Department of Pharmacology and Toxicology, Zydus Research Center, Ahmedabad, Gujarat, India. ^[5] Zydus Research Center, Ahmedabad, Gujarat, India. ^[6]

关键词 Bruton's tyrosine kinase cancer irreversible inhibitor rheumatoid arthritis xenograft

主题词动物(Animals);关节炎, 实验性(Arthritis, Experimental);关节炎, 类风湿(Arthritis, Rheumatoid);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);小鼠(Mice);肿瘤(Neoplasms);蛋白激酶抑制剂(Protein Kinase Inhibitors)

DOI 10.1002/prp2.565

PMID 32790160

发布时间 2024-03-29

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Pharmacology research & perspectives

2020年8卷4期

e00565页

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ZYBT1, a potent, irreversible Bruton's Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer.

Pharmacology research & perspectives

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Pharmacology research & perspectives

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ZYBT1, a potent, irreversible Bruton's Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer.

Pharmacology research & perspectives

相似文献

Pharmacology research & perspectives

相关期刊

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