Targeted LC-ESI-MS<sup>2</sup> characterization of human milk oligosaccharide diversity at 6 to 16 weeks post-partum reveals clear staging effects and distinctive milk groups.

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作者： Marko,Mank ^[1] ; Hans,Hauner ^[2] ; Albert J R,Heck ^[3] ; Bernd,Stahl ^[4]

作者单位： Danone Nutricia Research, Uppsalalaan 12, 3584 CT, Utrecht, The Netherlands. marko.mank@danone.com. ^[1] Else Kröner-Fresenius Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, Munich, Germany. ^[2] Nutritional Medicine Unit, Research Center for Nutrition and Food Sciences (ZIEL), Technische Universität München, Weihenstephaner Berg 1, 85354, Freising, Germany. ^[3] Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands. ^[4] Netherlands Proteomics Center, Padualaan 8, 3584 CH, Utrecht, The Netherlands. ^[5] Danone Nutricia Research, Uppsalalaan 12, 3584 CT, Utrecht, The Netherlands. ^[6] Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands. ^[7]

关键词 3-FL 6′-SL Human milk groups/milktyping Human milk oligosaccharides (HMOs)Principal component analysis (PCA)Secretor (Se) and Lewis (Le) gene–dependent or Secretor (Se) and Lewis (Le) gene–independent HMOs Stages of lactation Targeted LC-MS2