The <i>αβ</i>TCR mechanosensor exploits dynamic ectodomain allostery to optimize its ligand recognition site.

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第一作者： Wonmuk,Hwang

第一单位： Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843; hwm@tamu.edu ellis_reinherz@dfci.harvard.edu.

作者： Wonmuk,Hwang ^[1] ; Robert J,Mallis ^[2] ; Matthew J,Lang ^[3] ; Ellis L,Reinherz ^[4]

作者单位： Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843; hwm@tamu.edu ellis_reinherz@dfci.harvard.edu. ^[1] Department of Materials Science & Engineering, Texas A&M University, College Station, TX 77843. ^[2] Department of Physics & Astronomy, Texas A&M University, College Station, TX 77843. ^[3] School of Computational Sciences, Korea Institute for Advanced Study, Seoul, Korea 02455. ^[4] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115. ^[5] Department of Dermatology, Harvard Medical School, Boston, MA 02115. ^[6] Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115. ^[7] Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235. ^[8] Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37235. ^[9] Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115; hwm@tamu.edu ellis_reinherz@dfci.harvard.edu. ^[10] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115. ^[11] Department of Medicine, Harvard Medical School, Boston, MA 02115. ^[12]

关键词 T cell receptor catch bond dynamic allostery mechanoimmunology molecular dynamics

主题词人类(Humans);配体(Ligands);主要组织相容性复合物(Major Histocompatibility Complex);动力传导, 细胞(Mechanotransduction, Cellular);分子动力学模拟(Molecular Dynamics Simulation);受体, 抗原, T细胞, α-β(Receptors, Antigen, T-Cell, alpha-beta);T淋巴细胞(T-Lymphocytes)

DOI 10.1073/pnas.2005899117

PMID 32796106

发布时间 2021-11-16

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准确一般字义偏差语意偏离译文作用小提交