Exploring 3-hydroxyflavone scaffolds as mushroom tyrosinase inhibitors: synthesis, X-ray crystallography, antimicrobial, fluorescence behaviour, structure-activity relationship and molecular modelling studies.

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作者： Jamshaid,Ashraf ^[1] ; Ehsan Ullah,Mughal ^[1] ; Amina,Sadiq ^[2] ; Maryam,Bibi ^[1] ; Nafeesa,Naeem ^[1] ; Anser,Ali ^[3] ; Anam,Massadaq ^[3] ; Nighat,Fatima ^[4] ; Asif,Javid ^[1] ; Muhammad Naveed,Zafar ^[5] ; Bilal Ahmad,Khan ^[6] ; Muhammad Faizan,Nazar ^[1] ; Amara,Mumtaz ^[7] ; Muhammad Nawaz,Tahir ^[8] ; Masoud,Mirzaei ^[9]

作者单位： Department of Chemistry, University of Gujrat, Gujrat, Pakistan. ^[1] Department of Chemistry, Govt. College Women University, Sialkot, Pakistan. ^[2] Department of Zoology, Mirpur University of Science and Technology, Mirpur, Pakistan. ^[3] Department of Pharmacy, COMSATS University Islamabad, Abbotabad, Pakistan. ^[4] Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan. ^[5] Department of Chemistry, University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan. ^[6] Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan. ^[7] Department of Physics, University of Sargodha, Sargodha, Pakistan. ^[8] Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran. ^[9]

关键词 3-hydroxyflavones Algar-Flynn-Oyamada reaction antibacterial antifungal molecular docking studies tyrosinase enzyme inhibition