Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway.-论文-万方医学网

作者： Hui-Juan,Liu ^[1] ; Yuan,Qin ^[2] ; Zi-Han,Zhao ^[1] ; Yang,Zhang ^[2] ; Jia-Huan,Yang ^[1] ; Deng-Hui,Zhai ^[2] ; Fang,Cui ^[3] ; Ce,Luo ^[1] ; Man-Xi,Lu ^[2] ; Piao-Piao,Liu ^[1] ; Heng-Wei,Xu ^[2] ; Kun,Li ^[1] ; Bo,Sun ^[2] ; Shuang,Chen ^[1] ; Hong-Gang,Zhou ^[1] ; Cheng,Yang ^[1] ; Tao,Sun ^[1]

作者单位： State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China. ^[1] Tianjin Key Laboratory of Early Druggability Evaluation of Innovative Drugs and Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, China. ^[2] Department of Anesthesiology, Tianjin Fourth Central Hospital, Tianjin, China. ^[3] Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin Institute of Digestive Disease, Tianjin, China. ^[4]

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);细胞质膜微囊(Caveolae);细胞系, 肿瘤(Cell Line, Tumor);胞吞作用(Endocytosis);女(雌)性(Female);GTP磷酸水解酶类(GTP Phosphohydrolases);人类(Humans);香菇多糖(Lentinan);膜电位, 线粒体(Membrane Potential, Mitochondrial);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);线粒体(Mitochondria);线粒体膜转运蛋白质类(Mitochondrial Membrane Transport Proteins);纳米粒子(Nanoparticles);卵巢肿瘤(Ovarian Neoplasms);蛋白质组学(Proteomics);活性氧(Reactive Oxygen Species);硒(Selenium);信号传导(Signal Transduction);TNF受体相关因子3(TNF Receptor-Associated Factor 3);Toll样受体4(Toll-Like Receptor 4)

DOI 10.7150/thno.46467

PMID 32802180

发布时间 2022-11-28

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Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway.

Theranostics

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Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway.

Theranostics

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Theranostics

相关期刊

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