Oral Treatment with Iododiflunisal Delays Hippocampal Amyloid-β Formation in a Transgenic Mouse Model of Alzheimer's Disease: A Longitudinal in vivo Molecular Imaging Study1.

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作者： Luka,Rejc ^[1] ; Vanessa,Gómez-Vallejo ^[2] ; Xabier,Rios ^[2] ; Unai,Cossío ^[2] ; Zuriñe,Baz ^[2] ; Edurne,Mujica ^[3] ; Tiago,Gião ^[4] ; Ellen Y,Cotrina ^[5] ; Jesús,Jiménez-Barbero ^[6] ; Jordi,Quintana ^[7] ; Gemma,Arsequell ^[8] ; Isabel,Cardoso ^[9] ; Jordi,Llop ^[10]

作者单位： University of Ljubljana, Faculty of Chemistry and Chemical Technology, Ljubljana, Slovenia. ^[1] CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), San Sebastián, Guipúzcoa, Spain. ^[2] Biochemistry and Molecular Biology, EHU-UPV, Leioa, Spain. ^[3] IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal. ^[4] i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal. ^[5] Institut de Química Avançada de Catalunya (I.Q.A.C.-C.S.I.C.), Barcelona, Spain. ^[6] CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Bizkaia, Spain. ^[7] Ikerbasque, Basque Foundation for Science, Bilbao, Spain. ^[8] Department Organic Chemistry II, Faculty Science & Technology, EHU-UPV, Leioa, Spain. ^[9] Plataforma Drug Discovery, Parc Científic de Barcelona (PCB), Barcelona, Spain. ^[10] Centro de Investigación Biomédica en Red - Enfermedades Respiratorias (CIBERES). ^[11]

关键词 Alzheimer’s disease TTR/Aβ interaction disease-modifying drug positron emission tomography small-molecule chaperones transthyretin