Site-Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases.

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作者： Anass,Chiki ^[1] ; Jonathan,Ricci ^[1] ; Ramanath,Hegde ^[1] ; Luciano A,Abriata ^[2] ; Andreas,Reif ^[1] ; Driss,Boudeffa ^[1] ; Hilal A,Lashuel ^[1]

作者单位： Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Station 19, 1015, Lausanne, Switzerland. ^[1] Protein Production and Structure Core Facility and Laboratory for Biomolecular Modeling, Ecole Polytechnique Fédérale de Lausanne (EPFL) and Swiss Institute of Bioinformatics (SIB), 1015, Lausanne, Switzerland. ^[2]

关键词 Httex1 Huntington's disease NMR spectroscopy phosphorylation post-translational modifications

主题词外显子(Exons);人类(Humans);突变(Mutation);磷酰化(Phosphorylation);磷酸转移酶类(Phosphotransferases);蛋白质构象(Protein Conformation);重组蛋白质类(Recombinant Proteins)

DOI 10.1002/cbic.202000508

PMID 32805086

发布时间 2024-09-30

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