首页> Journal of molecular graphics & modelling> Insight into the structural and functional analysis of the impact of missense mutation on cytochrome P450 oxidoreductase.

Insight into the structural and functional analysis of the impact of missense mutation on cytochrome P450 oxidoreductase.

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第一作者： Rajalakshmi,Kumar

第一单位： Central Inter-Disciplinary Research Facility, Sri Balaji Vidyapeeth (Deemed to be University), Pillayarkuppam, Puducherry, 607 402, India.

作者： Rajalakshmi,Kumar ^[1] ; Manikandan,Jayaraman ^[2] ; Krishna,Ramadas ^[3] ; Adithan,Chandrasekaran ^[4]

作者单位： Central Inter-Disciplinary Research Facility, Sri Balaji Vidyapeeth (Deemed to be University), Pillayarkuppam, Puducherry, 607 402, India. ^[1] Centre for Bioinformatics, School of Life Sciences, Pondicherry University, Puducherry, 605 014, India. ^[2] Centre for Bioinformatics, School of Life Sciences, Pondicherry University, Puducherry, 605 014, India. Electronic address: ramadaskr@gmail.com. ^[3] Central Inter-Disciplinary Research Facility, Sri Balaji Vidyapeeth (Deemed to be University), Pillayarkuppam, Puducherry, 607 402, India. Electronic address: adithan50@gmail.com. ^[4]

关键词 Cytochrome P450 oxidoreductase Drug metabolism Free energy landscape Insilico Missense mutation Molecular dynamics simulation

主题词细胞色素P450酶系统(Cytochrome P-450 Enzyme System);分子动力学模拟(Molecular Dynamics Simulation);突变(Mutation);突变, 误义(Mutation, Missense);NADPH高铁血红素蛋白还原酶(NADPH-Ferrihemoprotein Reductase)

DOI 10.1016/j.jmgm.2020.107708

PMID 32805558

发布时间 2021-06-21

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