首页> Journal of proteome research> Integrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection.

Integrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection.

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第一作者： Torben,Kimhofer

第一单位： Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.

作者： Torben,Kimhofer ^[1] ; Samantha,Lodge ^[1] ; Luke,Whiley ^[2] ; Nicola,Gray ^[1] ; Ruey Leng,Loo ^[1] ; Nathan G,Lawler ^[1] ; Philipp,Nitschke ^[1] ; Sze-How,Bong ^[1] ; David L,Morrison ^[1] ; Sofina,Begum ^[3] ; Toby,Richards ^[4] ; Bu B,Yeap ^[4] ; Chris,Smith ^[5] ; Kenneth G C,Smith ^[5] ; Elaine,Holmes ^[6] ; Jeremy K,Nicholson ^[7]

作者单位： Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia. ^[1] Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.;Perron Institute for Neurological and Translational Science, Nedlands, Western Australia 6009, Australia. ^[2] Section for Nutrition Research, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K. ^[3] Medical School, Faculty of Health and Medical Sciences, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Harry Perkins Building, Murdoch, Perth, Western Australia 6150, Australia. ^[4] The Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, U.K. ^[5] Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.;Section for Nutrition Research, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K. ^[6] Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.;Medical School, Faculty of Health and Medical Sciences, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Harry Perkins Building, Murdoch, Perth, Western Australia 6150, Australia.;Institute of Global Health Innovation, Imperial College London, Level 1, Faculty Building South Kensington Campus, London SW7 2AZ, U.K. ^[7]

关键词 COVID-19 NMR spectroscopy SARS-CoV-2 amino acids biomarkers lipoproteins mass spectrometry metabolic phenotyping mosaic disease multiorgan damage systems model