Deployable CRISPR-Cas13a diagnostic tools to detect and report Ebola and Lassa virus cases in real-time.
作者:
Kayla G,Barnes [1]
;
Anna E,Lachenauer [2]
;
Adam,Nitido [3]
;
Sameed,Siddiqui [4]
;
Robin,Gross [5]
;
Brett,Beitzel [6]
;
Katherine J,Siddle [7]
;
Catherine A,Freije [8]
;
Bonnie,Dighero-Kemp [9]
;
Samar B,Mehta [10]
;
Amber,Carter [11]
;
Jessica,Uwanibe [8]
;
Fehintola,Ajogbasile [12]
;
Testimony,Olumade [8]
;
Ikponmwosa,Odia [7]
;
John Demby,Sandi [10]
;
Mambu,Momoh [8]
;
Hayden C,Metsky [13]
;
Chloe K,Boehm [8]
;
Aaron E,Lin [14]
;
Molly,Kemball [15]
;
Daniel J,Park [14]
;
Luis,Branco [15]
;
Matt,Boisen [14]
;
Brian,Sullivan [15]
;
Mihret F,Amare [16]
;
Abdulwasiu B,Tiamiyu [14]
;
Zahra F,Parker [17]
;
Michael,Iroezindu [14]
;
Donald S,Grant [17]
;
Kayvon,Modjarrad [8]
;
Cameron,Myhrvold [18]
;
Robert F,Garry [8]
;
Gustavo,Palacios [8]
;
Lisa E,Hensley [7]
;
Stephen F,Schaffner [8]
;
Christian T,Happi [12]
;
Andres,Colubri [8]
;
Pardis C,Sabeti [19]
作者单位:
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. kbarnes@broadinstitute.org.
[1]
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA. kbarnes@broadinstitute.org.
[2]
MRC-University of Glasgow Centre for Virus Research, Glasgow, UK. kbarnes@broadinstitute.org.
[3]
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. annalach@stanford.edu.
[4]
Stanford University School of Medicine, Stanford, California, USA. annalach@stanford.edu.
[5]
Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, 02139, USA.
[6]
Ph.D. Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, 02115, USA.
[7]
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
[8]
Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
[9]
Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland, USA.
[10]
Center for Genome Sciences, The United States Army Medical Research Institute for Infectious Disease, 1425 Porter Street, Fort Detrick, Maryland, 21702, USA.
[11]
Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.
[12]
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
[13]
African Center of Excellence for Genomics of Infectious Disease (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
[14]
Department of Biological Sciences, College of Natural Sciences, Redeemer's University, Ede, Osun State, Nigeria.
[15]
Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
[16]
Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.
[17]
Department of Electrical Engineering and Computer Science, MIT, Cambridge, Massachusetts, 02139, USA.
[18]
Zalgen Labs, Germantown, Maryland, USA.
[19]
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
[20]
Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
[21]
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
[22]
Henry M. Jackson Foundation Medical Research International, Abuja, Nigeria.
[23]
Ministry of Health and Sanitation, Freetown, Sierra Leone.
[24]
Tulane University School of Medicine, New Orleans, Los Angeles, 70112, USA.
[25]
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
[26]
Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.
[27]
主题词
抗体, 病毒(Antibodies, Viral);埃博拉病毒(Ebolavirus);出血热, 埃博拉(Hemorrhagic Fever, Ebola);拉沙热(Lassa Fever);拉沙病毒(Lassa virus)
DOI
10.1038/s41467-020-17994-9
PMID
32807807
发布时间
2021-08-17
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Nature communications
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