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Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress.

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第一作者： Suneeta,Chimalapati

第一单位： Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.;Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, United States.

作者： Suneeta,Chimalapati ^[1] ; Marcela,de Souza Santos ^[2] ; Alexander E,Lafrance ^[2] ; Ann,Ray ^[3] ; Wan-Ru,Lee ^[4] ; Giomar,Rivera-Cancel ^[5] ; Gonçalo,Vale ^[6] ; Krzysztof,Pawlowski ^[7] ; Matthew A,Mitsche ^[8] ; Jeffrey G,McDonald ^[8] ; Jen,Liou ^[4] ; Kim,Orth ^[9]

作者单位： Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.;Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, United States. ^[1] Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States. ^[2] Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, United States. ^[3] Department of Physiology, University of Texas Southwestern Medical Center, Dallas, United States. ^[4] Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States. ^[5] Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, United States. ^[6] Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.;Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw, Poland. ^[7] Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, United States.;Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, United States. ^[8] Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.;Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, United States.;Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States. ^[9]

关键词 T3SS VPA0226 cholesterol homeostasis egress infectious disease invasion microbiology vibrio parahaemolyticus

医学主题词细菌蛋白质类(Bacterial Proteins);胆固醇(Cholesterol);酯化(Esterification);脂肪酸类(Fatty Acids);基因组岛(Genomic Islands);脂肪酶(Lipase);副溶血性弧菌(Vibrio parahaemolyticus)

DOI 10.7554/eLife.58057

PMID 32808593

发布时间 2021-07-08

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