首页> Molecular oncology> AAV-mediated gene transfer of DNase I in the liver of mice with colorectal cancer reduces liver metastasis and restores local innate and adaptive immune response.

AAV-mediated gene transfer of DNase I in the liver of mice with colorectal cancer reduces liver metastasis and restores local innate and adaptive immune response.

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第一作者： Yujia,Xia

第一单位： Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.;Department of Gastroenterology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.

作者： Yujia,Xia ^[1] ; Jiayi,He ^[2] ; Hongji,Zhang ^[3] ; Han,Wang ^[1] ; George,Tetz ^[4] ; Casey A,Maguire ^[5] ; Yu,Wang ^[3] ; Amblessed,Onuma ^[3] ; Dmitry,Genkin ^[6] ; Victor,Tetz ^[7] ; Alexey,Stepanov ^[8] ; Stanislav,Terekhov ^[8] ; Valeria,Ukrainskaya ^[8] ; Hai,Huang ^[3] ; Allan,Tsung ^[3]

作者单位： Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.;Department of Gastroenterology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China. ^[1] Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.;Department of Pediatrics, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China. ^[2] Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA. ^[3] Human Microbiology Institute, New York, NY, USA.;CLS-Therapeutics, New York, NY, USA. ^[4] Molecular Neurogenetics Unit, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA. ^[5] CLS-Therapeutics, New York, NY, USA. ^[6] Human Microbiology Institute, New York, NY, USA. ^[7] M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. ^[8]

关键词 Deoxyribonuclease I adeno-associated virus metastatic colorectal cancer neutrophil extracellular traps