Mn<sup>2+</sup> Directly Activates cGAS and Structural Analysis Suggests Mn<sup>2+</sup> Induces a Noncanonical Catalytic Synthesis of 2'3'-cGAMP.

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作者： Zhen,Zhao ^[1] ; Zhixing,Ma ^[1] ; Bo,Wang ^[2] ; Yukun,Guan ^[1] ; Xiao-Dong,Su ^[3] ; Zhengfan,Jiang ^[4]

作者单位： Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China. ^[1] State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China; Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing 100871, China. ^[2] State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China; Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing 100871, China. Electronic address: xdsu@pku.edu.cn. ^[3] Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China. Electronic address: jiangzf@pku.edu.cn. ^[4]

关键词 2’3’-cGAMP Mn(2+)cGAS catalytic synthesis innate immunity type I-IFNs

主题词动物(Animals);人类(Humans);免疫, 先天(Immunity, Innate);模型, 分子(Models, Molecular);核苷酸类, 环(Nucleotides, Cyclic)

DOI 10.1016/j.celrep.2020.108053

PMID 32814054

发布时间 2021-05-28

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