Longitudinal white matter and cognitive development in pediatric carriers of the apolipoprotein ε4 allele.

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作者： Justin,Remer ^[1] ; Douglas C,Dean ^[2] ; Kewei,Chen ^[3] ; Rebecca A,Reiman ^[4] ; Matthew J,Huentelman ^[4] ; Eric M,Reiman ^[5] ; Sean C L,Deoni ^[6]

作者单位： Advanced Baby Imaging Lab, Rhode Island Hospital, Providence, RI, USA; Department of Pediatrics, Warren Alpert Medical School at Brown University, Providence RI, USA. Electronic address: Justinremer.md@gmail.com. ^[1] Department of Pediatrics, University of Wisconsin-Madison, Madison WI 53705 USA; Department of Medical Physics, University of Wisconsin-Madison, Madison WI 5305 USA; Waisman Center, University of Wisconsin-Madison, Madison WI 53705 USA. ^[2] Arizona Alzheimer's Consortium, University of Arizona School of Medicine, Tucson and Phoenix AZ, USA; Banner Alzheimer's Institute, Phoenix, AZ, USA; University of Arizona College of Medicine, Phoenix, AZ, USA; Arizona State University, Phoenix, AZ, USA. ^[3] Banner Alzheimer's Institute, Phoenix, AZ, USA; Neurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ, USA. ^[4] Arizona Alzheimer's Consortium, University of Arizona School of Medicine, Tucson and Phoenix AZ, USA; Banner Alzheimer's Institute, Phoenix, AZ, USA; University of Arizona College of Medicine, Phoenix, AZ, USA; Arizona State University, Phoenix, AZ, USA; Neurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ, USA. ^[5] Advanced Baby Imaging Lab, Rhode Island Hospital, Providence, RI, USA; Department of Pediatrics, Warren Alpert Medical School at Brown University, Providence RI, USA; Maternal, Newborn, and Child Health Discovery and Tools, Bill and Melinda Gates Foundation; Seattle WA, USA. ^[6]

关键词 APOE Alzheimer's Disease Cognitive Development Genetic predisposition to disease Genetic risk MRI Myelin Neurodevelopment Pediatric brain development Radiology White matter mcDESPOT