A common CORIN variant in hypertension reduces corin intracellular trafficking by exposing an inhibitory N-terminus.

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第一作者： Meiling,He

第一单位： Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou, China.

作者： Meiling,He ^[1] ; Yue,Zhang ^[2] ; Hui,Li ^[2] ; Meng,Liu ^[1] ; Ningzheng,Dong ^[3] ; Qingyu,Wu ^[4]

作者单位： Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou, China. ^[1] Central Laboratory and Department of Obstetrics and Gynecology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China. ^[2] Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou, China; Key Laboratory of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China. Electronic address: ningzhengdong@suda.edu.cn. ^[3] Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou, China; Cardiovascular & Metabolic Sciences, Cleveland Clinic, Cleveland, OH, USA. Electronic address: wuq@ccf.org. ^[4]

关键词 Corin Cytoplasmic tail Intracellular trafficking Protease Transmembrane protein

主题词 HEK293细胞(HEK293 Cells);人类(Humans);高血压(Hypertension);突变(Mutation);蛋白质转运(Protein Transport);丝氨酸内肽酶类(Serine Endopeptidases)

DOI 10.1016/j.bbrc.2020.07.023

PMID 32828311

发布时间 2021-02-24

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