Repurposing metformin, simvastatin and digoxin as a combination for targeted therapy for pancreatic ductal adenocarcinoma.

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第一作者： Shi-He,Liu

第一单位： Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA; Department of Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA. Electronic address: Shi-He.Liu@Utoledo.edu.

作者： Shi-He,Liu ^[1] ; Juehua,Yu ^[2] ; Justin F,Creeden ^[3] ; Jeffrey M,Sutton ^[4] ; Stephen,Markowiak ^[4] ; Robbi,Sanchez ^[2] ; John,Nemunaitis ^[5] ; Andrea,Kalinoski ^[4] ; Jian-Ting,Zhang ^[6] ; Robert,Damoiseaux ^[7] ; Paul,Erhardt ^[8] ; F Charles,Brunicardi ^[3]

作者单位： Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA; Department of Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA. Electronic address: Shi-He.Liu@Utoledo.edu. ^[1] Department of Surgery, University of California Los Angeles, Los Angeles, CA, 90095, USA. ^[2] Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA; Department of Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA. ^[3] Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA. ^[4] Department of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA. ^[5] Department of Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA. ^[6] Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, 90095, USA. ^[7] Department of Medicinal and Biological Chemistry, University of Toledo College of Pharmacy and Pharmaceutical Sciences, Toledo, OH, 43614, USA. ^[8]

关键词 BIRC5 FDA Approved drug libraries High throughput screening PDX1 Super promoter