首页> Science advances> Inhibition of Polo-like kinase 1 (PLK1) facilitates the elimination of HIV-1 viral reservoirs in CD4<sup>+</sup> T cells ex vivo.

Inhibition of Polo-like kinase 1 (PLK1) facilitates the elimination of HIV-1 viral reservoirs in CD4<sup>+</sup> T cells ex vivo.

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第一作者： Dawei,Zhou

第一单位： Department of Pathology, Ohio State University College of Medicine, Columbus, OH 43210, USA.

作者： Dawei,Zhou ^[1] ; Tsuyoshi,Hayashi ^[2] ; Maxime,Jean ^[2] ; Weili,Kong ^[1] ; Guillaume,Fiches ^[1] ; Ayan,Biswas ^[1] ; Shuai,Liu ^[3] ; Hailemichael O,Yosief ^[3] ; Xiaofeng,Zhang ^[3] ; Jay,Bradner ^[4] ; Jun,Qi ^[5] ; Wei,Zhang ^[3] ; Netty,Santoso ^[1] ; Jian,Zhu ^[1]

作者单位： Department of Pathology, Ohio State University College of Medicine, Columbus, OH 43210, USA. ^[1] Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester NY 14642, USA. ^[2] Chemistry Department, College of Science and Mathematics, University of Massachusetts at Boston, Boston, MA 02125, USA. ^[3] Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA. ^[4] Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. ^[5]

医学主题词 CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);细胞周期蛋白质类(Cell Cycle Proteins);HIV感染(HIV Infections);HIV-1(HIV-1);人类(Humans);原癌基因蛋白质类(Proto-Oncogene Proteins);病毒激活(Virus Activation);病毒潜伏期(Virus Latency)

DOI 10.1126/sciadv.aba1941

PMID 32832623

发布时间 2024-04-28

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Inhibition of Polo-like kinase 1 (PLK1) facilitates the elimination of HIV-1 viral reservoirs in CD4<sup>+</sup> T cells ex vivo.

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Inhibition of Polo-like kinase 1 (PLK1) facilitates the elimination of HIV-1 viral reservoirs in CD4<sup>+</sup> T cells ex vivo.

Science advances

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Science advances

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