A novel quinolinylmethyl substituted ethylenediamine compound exerts anti-cancer effects via stimulating the accumulation of reactive oxygen species and NO in hepatocellular carcinoma cells.

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作者： Fujun,Jin ^[1] ; Rongze,Wang ^[2] ; Yexuan,Zhu ^[2] ; Jingyi,Chen ^[2] ; Wei,Cao ^[2] ; Yiliang,Wang ^[2] ; Yanting,Wu ^[2] ; Xiaowei,Song ^[2] ; Yunsheng,Huang ^[3] ; Jun,Dong ^[4] ; Zhe,Ren ^[5]

作者单位： Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Department of Pathophysiology, GHM Institute of CNS Regeneration, School of Medicine, Jinan University, Guangzhou, 510632, China. ^[1] Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China. ^[2] School of Pharmacy, Guangdong Medical University, 1 Xincheng Ave, Songshan Lake Technology Park, Dongguan, Guangdong, 523808, China. Electronic address: yshuang@gdmu.edu.cn. ^[3] Department of Pathophysiology, GHM Institute of CNS Regeneration, School of Medicine, Jinan University, Guangzhou, 510632, China. Electronic address: dongjunbox@163.com. ^[4] Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China. Electronic address: rz62@163.com. ^[5]

关键词 Apoptosis Hepatocellular carcinoma Nitric oxide Reactive oxygen species