Heterologous Expression of the Unusual Terreazepine Biosynthetic Gene Cluster Reveals a Promising Approach for Identifying New Chemical Scaffolds.

导出 OA

翻译打印收藏纠错

第一作者： Lindsay K,Caesar

第一单位： Department of Chemistry, Northwestern University, Evanston, Illinois, USA.

作者： Lindsay K,Caesar ^[1] ; Matthew T,Robey ^[2] ; Michael,Swyers ^[3] ; Md N,Islam ^[3] ; Rosa,Ye ^[3] ; Purav P,Vagadia ^[4] ; Gary E,Schiltz ^[4] ; Paul M,Thomas ^[5] ; Chengcang C,Wu ^[6] ; Neil L,Kelleher ^[2] ; Nancy P,Keller ^[7] ; Jin Woo,Bok ^[8]

作者单位： Department of Chemistry, Northwestern University, Evanston, Illinois, USA. ^[1] Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA. ^[2] Intact Genomics, Inc., St. Louis, Missouri, USA. ^[3] Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois, USA. ^[4] Department of Pharmacology, Northwestern University, Chicago, Illinois, USA. ^[5] Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. ^[6] Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA. ^[7] Intact Genomics, Inc., St. Louis, Missouri, USA cwu@intactgenomics.com n-kelleher@northwestern.edu npkeller@wisc.edu jbok@wisc.edu. ^[8] Department of Chemistry, Northwestern University, Evanston, Illinois, USA cwu@intactgenomics.com n-kelleher@northwestern.edu npkeller@wisc.edu jbok@wisc.edu. ^[9] Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA cwu@intactgenomics.com n-kelleher@northwestern.edu npkeller@wisc.edu jbok@wisc.edu. ^[10] Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA. ^[11]

关键词 Aspergillus Aspergillus nidulans Aspergillus terreus IDO NRPS biosynthetic gene cluster genome mining heterologous expression indoleamine 2,3-dioxygenase kynurenine natural products