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Genetic variants and functional pathways associated with resilience to Alzheimer's disease.

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第一作者： Logan,Dumitrescu

第一单位： Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.;Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.

作者： Logan,Dumitrescu ^[1] ; Emily R,Mahoney ^[1] ; Shubhabrata,Mukherjee ^[2] ; Michael L,Lee ^[2] ; William S,Bush ^[3] ; Corinne D,Engelman ^[4] ; Qiongshi,Lu ^[5] ; David W,Fardo ^[6] ; Emily H,Trittschuh ^[7] ; Jesse,Mez ^[8] ; Catherine,Kaczorowski ^[9] ; Hector,Hernandez Saucedo ^[10] ; Keith F,Widaman ^[11] ; Rachel,Buckley ^[12] ; Michael,Properzi ^[13] ; Elizabeth,Mormino ^[14] ; Hyun-Sik,Yang ^[15] ; Tessa,Harrison ^[16] ; Trey,Hedden ^[17] ; Kwangsik,Nho ^[18] ; Shea J,Andrews ^[17] ; Doug,Tommet ^[19] ; Niran,Hadad ^[9] ; R Elizabeth,Sanders ^[2] ; Douglas M,Ruderfer ^[20] ; Katherine A,Gifford ^[21] ; Annah M,Moore ^[1] ; Francis,Cambronero ^[21] ; Xiaoyuan,Zhong ^[5] ; Neha S,Raghavan ^[22] ; Badri,Vardarajan ^[22] ; Alzheimer’s Disease Neuroimaging Initiative (ADNI) ^[23] ; Alzheimer’s Disease Genetics Consortium (ADGC), A4 Study Team ^[24] ; Margaret A,Pericak-Vance ^[25] ; Lindsay A,Farrer ^[26] ; Li-San,Wang ^[25] ; Carlos,Cruchaga ^[20] ; Gerard,Schellenberg ^[3] ; Nancy J,Cox ^[27] ; Jonathan L,Haines ^[28] ; C Dirk,Keene ^[29] ; Andrew J,Saykin ^[13] ; Eric B,Larson ^[22] ; Reisa A,Sperling ^[30] ; Richard,Mayeux ^[30] ; David A,Bennett ^[2] ; Julie A,Schneider ^[21] ; Paul K,Crane ^[1] ; Angela L,Jefferson ; Timothy J,Hohman

作者单位： Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.;Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA. ^[1] Department of Medicine, University of Washington, Seattle, WA, USA. ^[2] Cleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA. ^[3] Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. ^[4] Department of Statistics, University of Wisconsin-Madison, Madison, WI, USA.;Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA. ^[5] Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, KY, USA.;Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA. ^[6] Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.;VA Puget Sound Health Care System, GRECC, Seattle, WA, USA. ^[7] Deparment of Neurology, Boston University School of Medicine, Boston, MA, USA. ^[8] The Jackson Laboratory, Bar Harbor, ME, USA. ^[9] UC Davis Alzheimer's Disease Research Center, Department of Neurology, University of California Davis Medical Center, Sacramento, CA, USA. ^[10] University of California at Riverside, Riverside, CA, USA. ^[11] Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.;Center for Alzheimer's Research and Treatment, Department of Neurology, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.;Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia. ^[12] Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA. ^[13] Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA. ^[14] Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.;Center for Alzheimer's Research and Treatment, Department of Neurology, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA. ^[15] Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA. ^[16] Icahn School of Medicine at Mount Sinai, New York City, NY, USA. ^[17] Department of Radiology and Imaging Sciences, Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.;Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA. ^[18] Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, RI, USA. ^[19] Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA. ^[20] Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA. ^[21] Department of Neurology, Columbia University, New York, NY, USA.;The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University, New York, NY, USA.;The Institute for Genomic Medicine, Columbia University Medical Center and The New York Presbyterian Hospital, New York, NY, USA. ^[22] John P. Hussman Institute for Human Genomics, University of Miami School of Medicine, Miami, FL, USA. ^[23] Deparment of Neurology, Boston University School of Medicine, Boston, MA, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.;Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA. ^[24] Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. ^[25] Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. ^[26] Department of Pathology, University of Washington, Seattle, WA, USA. ^[27] Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA. ^[28] Department of Medicine, University of Washington, Seattle, WA, USA.;Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. ^[29] Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. ^[30]

关键词 Alzheimer’s disease GWAS amyloid reserve resilience