Clinical implications of HER2 mRNA expression and intrinsic subtype in refractory HER2-positive metastatic breast cancer treated with pan-HER inhibitor, poziotinib.

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第一作者： Ji-Yeon,Kim

第一单位： Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea.

作者： Ji-Yeon,Kim ^[1] ; Kyunghee,Park ^[2] ; Seock-Ah,Im ^[3] ; Kyung Hae,Jung ^[4] ; Joohyuk,Sohn ^[5] ; Keun Seok,Lee ^[6] ; Jee Hyun,Kim ^[7] ; Yaewon,Yang ^[8] ; Yeon Hee,Park ^[9]

作者单位： Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea. ^[1] Samsung Genome Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, Korea. ^[2] Division of Hematology-Oncology, Department of Internal Medicine, Seoul National University Hospital, Seoul National University School of Medicine, Seoul, 03080, Korea. ^[3] Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Korea. ^[4] Department of Internal Medicine, Yonsei Cancer Center, Seoul, 03722, Korea. ^[5] Center for Breast Cancer, National Cancer Center Hospital, Goyang, 10408, Korea. ^[6] Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, 13620, Korea. ^[7] Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, 28644, Korea. ^[8] Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea. yhparkhmo@skku.edu. ^[9]

关键词 Genetic alteration HER2?+?metastatic breast cancer Intrinsic molecular subtype Prediction model

主题词乳腺肿瘤(Breast Neoplasms);女(雌)性(Female);人类(Humans);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);预后(Prognosis);喹唑啉类(Quinazolines);RNA, 信使(RNA, Messenger)

DOI 10.1007/s10549-020-05891-0

PMID 32860168

发布时间 2021-06-23

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