Prebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced apnoea and hypertension in adult rats.

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作者： Karen M,O'Connor ^[1] ; Eric F,Lucking ^[2] ; Thomaz F S,Bastiaanssen ^[3] ; Veronica L,Peterson ^[4] ; Fiona,Crispie ^[5] ; Paul D,Cotter ^[5] ; Gerard,Clarke ^[6] ; John F,Cryan ^[3] ; Ken D,O'Halloran ^[7]

作者单位： Department of Physiology, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland; Department of Anatomy & Neuroscience, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland; APC Microbiome Ireland, University College Cork, Cork, Ireland. ^[1] Department of Physiology, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland. ^[2] Department of Anatomy & Neuroscience, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland; APC Microbiome Ireland, University College Cork, Cork, Ireland. ^[3] Teagasc Food Research Centre, Moorepark, Fermoy, County Cork, Ireland. ^[4] APC Microbiome Ireland, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, County Cork, Ireland. ^[5] APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Psychiatry and Neurobehavioural Science, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland. ^[6] Department of Physiology, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland; APC Microbiome Ireland, University College Cork, Cork, Ireland. Electronic address: k.ohalloran@ucc.ie. ^[7]

关键词 Apnoea Autonomic dysfunction Chronic intermittent hypoxia Hypertension Microbiota Neurochemistry Prebiotics Short-chain fatty acids Vagus

主题词动物(Animals);呼吸暂停(Apnea);血气分析(Blood Gas Analysis);脑干(Brain Stem);儿茶酚胺类(Catecholamines);细胞因子类(Cytokines);疾病模型, 动物(Disease Models, Animal);疾病易感性(Disease Susceptibility);脂肪酸类, 挥发性(Fatty Acids, Volatile);粪便(Feces);心脏功能试验(Heart Function Tests);高血压(Hypertension);炎症介导素类(Inflammation Mediators);男(雄)性(Male);益生元(Prebiotics);大鼠(Rats);呼吸功能试验(Respiratory Function Tests)

DOI 10.1016/j.ebiom.2020.102968

PMID 32861200

发布时间 2024-03-29

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EBioMedicine

2020年59卷

102968页

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Prebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced apnoea and hypertension in adult rats.

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Prebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced apnoea and hypertension in adult rats.

EBioMedicine

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EBioMedicine

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