IGF-1R stimulation alters microglial polarization via TLR4/NF-κB pathway after cerebral hemorrhage in mice.

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作者： Zhezhe,Sun ^[1] ; Ke,Wu ^[2] ; Lei,Gu ^[3] ; Lijie,Huang ^[4] ; Qichuan,Zhuge ^[5] ; Su,Yang ^[6] ; Zhenzhong,Wang ^[7]

作者单位： Department of Cerebrovascular, The Affiliated Hospital of Medical School of Ningbo University, Ningbo 315000, China. ^[1] Zhejiang University, Hangzhou 310000, China. ^[2] Department of Rehabilitation, Ningbo Medical Center Lihuili Hospital, Ningbo 315000, China. ^[3] Department of Neurosurgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. ^[4] Department of Neurosurgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: drzhuge@wzhospital.cn. ^[5] Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: yangsu0575@163.com. ^[6] Department of Neurosurgery, Yuyao People's Hospital, Ningbo 315000, China. Electronic address: kjkyyhospital@163.com. ^[7]

关键词 Intracerebral hemorrhage TLR4/NF-κB insulin-like growth factor-1 microglial polarization neural stem cells