Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization.

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作者： Taha,Azad ^[1] ; Ragunath,Singaravelu ^[2] ; Mathieu J F,Crupi ^[1] ; Taylor,Jamieson ^[2] ; Jaahnavi,Dave ^[1] ; Emily E F,Brown ^[2] ; Reza,Rezaei ^[1] ; Zaid,Taha ^[2] ; Stephen,Boulton ^[1] ; Nikolas T,Martin ^[2] ; Abera,Surendran ^[1] ; Joanna,Poutou ^[2] ; Mina,Ghahremani ^[1] ; Kazem,Nouri ^[2] ; Jack T,Whelan ^[1] ; Jessie,Duong ^[2] ; Sarah,Tucker ^[1] ; Jean-Simon,Diallo ^[2] ; John C,Bell ^[1] ; Carolina S,Ilkow ^[2]

作者单位： Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada. ^[1] Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada. ^[2] Department of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada. ^[3] Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada. ^[4]

关键词 SARS-CoV-2 receptor-binding domain spike protein transmembrane domain trimerization vaccine development

DOI 10.3390/membranes10090215

PMID 32872641

发布时间 2020-10-23

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