Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses.

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作者： Jie,Chen ^[1] ; Shane M,Harding ^[1] ; Ramakrishnan,Natesan ^[1] ; Lei,Tian ^[1] ; Joseph L,Benci ^[2] ; Weihua,Li ^[1] ; Andy J,Minn ^[2] ; Irfan A,Asangani ^[3] ; Roger A,Greenberg ^[4]

作者单位： Department of Cancer Biology, Penn Center for Genome Integrity, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[1] Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[2] Department of Cancer Biology, Penn Center for Genome Integrity, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[3] Department of Cancer Biology, Penn Center for Genome Integrity, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: rogergr@pennmedicine.upenn.edu. ^[4]

关键词 ATR DNA damage RIG-I anti-tumor immune response cGAS cell cycle checkpoint inflammatory signaling p53

主题词细胞周期蛋白质类(Cell Cycle Proteins);DNA(DNA);人类(Humans);免疫(Immunity);肿瘤(Neoplasms);RNA(RNA);信号传导(Signal Transduction)

DOI 10.1016/j.celrep.2020.108080

PMID 32877684

发布时间 2021-05-28

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