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Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML.

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第一作者： James S,Smith

第一单位： Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, BT9 7AE, Northern Ireland, UK.

作者： James S,Smith ^[1] ; Katrina M,Lappin ^[1] ; Stephanie G,Craig ^[1] ; Fabio G,Liberante ^[2] ; Clare M,Crean ^[1] ; Simon S,McDade ^[1] ; Alexander,Thompson ^[3] ; Ken I,Mills ^[4] ; Kienan I,Savage ^[5]

作者单位： Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, BT9 7AE, Northern Ireland, UK. ^[1] Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, BT9 7AE, Northern Ireland, UK.;Wellcome Sanger Institute, Cambridge, UK. ^[2] Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, BT9 7AE, Northern Ireland, UK.;Division of Cancer and Stem Cells, School of Medicine, Wolfson Centre for Stem Cells, Tissue Engineering & Modelling (STEM), University of Nottingham, Nottingham, NG7 2RD, UK. ^[3] Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, BT9 7AE, Northern Ireland, UK. k.mills@qub.ac.uk. ^[4] Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, BT9 7AE, Northern Ireland, UK. k.savage@qub.ac.uk. ^[5]

关键词 Acute myeloid leukaemia ChIP-seq Cohesion HOX HiChIP MAPK pathway RNA-seq STAG2

医学主题词细胞周期蛋白质类(Cell Cycle Proteins);染色质(Chromatin);人类(Humans);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);突变(Mutation);骨髓增生异常综合征(Myelodysplastic Syndromes)

DOI 10.1186/s12967-020-02500-y

PMID 32883299

发布时间 2022-05-31

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