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Gabapentin Inhibits Multiple Steps in the Amyloid Beta Toxicity Cascade.

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第一作者： Juliana,González-Sanmiguel

第一单位： Laboratory of Neurophysiology, Department of Physiology, Universidad de Concepción, Concepción 4030000, Chile.

作者： Juliana,González-Sanmiguel ^[1] ; Carlos F,Burgos ^[1] ; Denisse,Bascuñán ^[1] ; Eduardo J,Fernández-Pérez ^[1] ; Nicolás,Riffo-Lepe ^[1] ; Subramanian,Boopathi ^[2] ; Arturo,Fernández-Pérez ^[3] ; Catalina,Bobadilla-Azócar ^[1] ; Wendy,González ^[4] ; Maximiliano,Figueroa ^[5] ; Benjamín,Vicente ^[6] ; Luis G,Aguayo ^[7]

作者单位： Laboratory of Neurophysiology, Department of Physiology, Universidad de Concepción, Concepción 4030000, Chile. ^[1] The Center for Bioinformatics and Molecular Simulations (CBSM), Universidad de Talca, Talca 3460000, Chile. ^[2] Department of Physics, University of Bío-Bío, Concepción 4030000, Chile. ^[3] The Center for Bioinformatics and Molecular Simulations (CBSM), Universidad de Talca, Talca 3460000, Chile.;Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Universidad de Talca, Talca 3460000, Chile. ^[4] Laboratory of Molecular Biophysics, Department of Biochemistry and Molecular Biology, Universidad de Concepción, Concepción 4030000, Chile. ^[5] Department of Psychiatry and Mental Health, Universidad de Concepcion, Concepción 4030000, Chile.;Program on Neuroscience, Psychiatry and Mental Health, Universidad de Concepcion, Concepción 4030000, Chile. ^[6] Laboratory of Neurophysiology, Department of Physiology, Universidad de Concepción, Concepción 4030000, Chile.;Program on Neuroscience, Psychiatry and Mental Health, Universidad de Concepcion, Concepción 4030000, Chile. ^[7]

关键词 Alzheimer’s disease Amyloid beta (Aβ)drug repurposing gabapentin (GBP)neurodegeneration neuroprotection

医学主题词阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);海马(Hippocampus);人类(Humans);神经元(Neurons);肽碎片(Peptide Fragments)

DOI 10.1021/acschemneuro.0c00414

PMID 32886489

发布时间 2021-06-18

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准确一般字义偏差语意偏离译文作用小提交