首页> Bioorganic chemistry> Design and synthesis of novel desfluoroquinolone-aminopyrimidine hybrids as potent anti-MRSA agents with low hERG activity.

Design and synthesis of novel desfluoroquinolone-aminopyrimidine hybrids as potent anti-MRSA agents with low hERG activity.

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第一作者： Runzhe,Song

第一单位： Department of Chemistry, Fudan University, 2005 Songhu Road, Yangpu District, Shanghai 200438, China.

作者： Runzhe,Song ^[1] ; Yue,Wang ^[1] ; Minghui,Wang ^[2] ; Ruixuan,Gao ^[2] ; Teng,Yang ^[3] ; Song,Yang ^[4] ; Cai-Guang,Yang ^[5] ; Yongsheng,Jin ^[6] ; Siyuan,Zou ^[1] ; Jianfeng,Cai ^[7] ; Renhua,Fan ^[8] ; Qiuqin,He ^[9]

作者单位： Department of Chemistry, Fudan University, 2005 Songhu Road, Yangpu District, Shanghai 200438, China. ^[1] Department of Chemistry, University of South Florida, Tampa, FL 33620, United States. ^[2] State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals, Guizhou University, Guiyang 550025, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ^[3] State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals, Guizhou University, Guiyang 550025, China. ^[4] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ^[5] School of Pharmacy, The Second Military Medical University, Shanghai 200433, China. ^[6] Department of Chemistry, University of South Florida, Tampa, FL 33620, United States. Electronic address: jianfengcai@usf.edu. ^[7] Department of Chemistry, Fudan University, 2005 Songhu Road, Yangpu District, Shanghai 200438, China. Electronic address: rhfan@fudan.edu.cn. ^[8] Department of Chemistry, Fudan University, 2005 Songhu Road, Yangpu District, Shanghai 200438, China. Electronic address: qqhe@fudan.edu.cn. ^[9]

关键词 Aminopyrimidine Anti-MRSA Desfluoroquinolone Hybrids hERG activity

主题词荧光喹诺酮类(Fluoroquinolones);人类(Humans);耐甲氧西林金黄色葡萄球菌(Methicillin-Resistant Staphylococcus aureus);分子结构(Molecular Structure);嘧啶类(Pyrimidines);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bioorg.2020.104176

PMID 32891858

发布时间 2021-03-02

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准确一般字义偏差语意偏离译文作用小提交