Structure-activity relationship study of novel quinazoline-based 1,6-naphthyridinones as MET inhibitors with potent antitumor efficacy.

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第一作者： Lin-Sheng,Zhuo

第一单位： Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China.

作者： Lin-Sheng,Zhuo ^[1] ; Feng-Xu,Wu ^[1] ; Ming-Shu,Wang ^[1] ; Hong-Chuang,Xu ^[1] ; Fan-Peng,Yang ^[1] ; Yan-Guang,Tian ^[1] ; Xing-E,Zhao ^[2] ; Zhi-Hui,Ming ^[2] ; Xiao-Lei,Zhu ^[1] ; Ge-Fei,Hao ^[3] ; Wei,Huang ^[4]

作者单位： Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China. ^[1] Jiangsu Key Laboratory of Molecular Targeted Antitumor Drug Research, Jiangsu Simcere Pharmaceutical Co. Ltd, Nanjing, 210042, PR China. ^[2] Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China. Electronic address: gefei_hao@foxmail.com. ^[3] Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China. Electronic address: weihuangwuhan@126.com. ^[4]

关键词 1,6-naphthyridone Antitumor MET kinase Inhibitor Quinazoline Structure-activity relationship