首页> Nature communications> Linkage of genetic drivers and strain-specific germline variants confound mouse cancer genome analyses.

Linkage of genetic drivers and strain-specific germline variants confound mouse cancer genome analyses.

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第一作者： Sebastian,Mueller

第一单位： Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, 81675, Munich, Germany.;Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technische Universität München, 81675, Munich, Germany.

作者： Sebastian,Mueller ^[1] ; Sebastian,Lange ^[2] ; Katharina A N,Collins ^[2] ; Stefan,Krebs ^[3] ; Helmut,Blum ^[3] ; Günter,Schneider ^[4] ; Lena,Rad ^[5] ; Dieter,Saur ^[6] ; Roland,Rad ^[7]

作者单位： Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, 81675, Munich, Germany.;Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technische Universität München, 81675, Munich, Germany. ^[1] Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, 81675, Munich, Germany.;Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technische Universität München, 81675, Munich, Germany.;Department of Medicine II, Klinikum rechts der Isar, School of Medicine, Technische Universität München, 81675, Munich, Germany. ^[2] Laboratory for Functional Genome Analysis, Gene Center, Ludwig-Maximilians-Universität München, 81377, Munich, Germany. ^[3] Department of Medicine II, Klinikum rechts der Isar, School of Medicine, Technische Universität München, 81675, Munich, Germany. ^[4] Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technische Universität München, 81675, Munich, Germany.;Institute for Experimental Cancer Therapy, School of Medicine, Technische Universität München, 81675, Munich, Germany. ^[5] Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technische Universität München, 81675, Munich, Germany.;Department of Medicine II, Klinikum rechts der Isar, School of Medicine, Technische Universität München, 81675, Munich, Germany.;Institute for Experimental Cancer Therapy, School of Medicine, Technische Universität München, 81675, Munich, Germany.;German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. ^[6] Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, 81675, Munich, Germany. roland.rad@tum.de.;Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technische Universität München, 81675, Munich, Germany. roland.rad@tum.de.;Department of Medicine II, Klinikum rechts der Isar, School of Medicine, Technische Universität München, 81675, Munich, Germany. roland.rad@tum.de.;German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. roland.rad@tum.de. ^[7]

医学主题词动物(Animals);基因连锁(Genetic Linkage);全基因组关联研究(Genome-Wide Association Study);生殖细胞(Germ Cells);小鼠(Mice);胰腺肿瘤(Pancreatic Neoplasms)

DOI 10.1038/s41467-020-18095-3

PMID 32901003

发布时间 2021-09-08

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