首页> Journal of medicinal chemistry> Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.

Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.

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第一作者： Frédéric,Labéguère

第一单位： Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France.

作者： Frédéric,Labéguère ^[1] ; Sonia,Dupont ^[1] ; Luke,Alvey ^[1] ; Florilène,Soulas ^[1] ; Gregory,Newsome ^[1] ; Amynata,Tirera ^[1] ; Vanessa,Quenehen ^[1] ; Thi Thu Trang,Mai ^[1] ; Pierre,Deprez ^[1] ; Roland,Blanqué ^[1] ; Line,Oste ^[2] ; Sandrine,Le Tallec ^[1] ; Steve,De Vos ^[2] ; Annick,Hagers ^[2] ; Ann,Vandevelde ^[2] ; Luc,Nelles ^[2] ; Nele,Vandervoort ^[2] ; Katja,Conrath ^[2] ; Thierry,Christophe ^[2] ; Ellen,van der Aar ^[2] ; Emanuelle,Wakselman ^[1] ; Didier,Merciris ^[1] ; Céline,Cottereaux ^[1] ; Cécile,da Costa ^[1] ; Laurent,Saniere ^[1] ; Philippe,Clement-Lacroix ^[1] ; Laura,Jenkins ^[3] ; Graeme,Milligan ^[3] ; Stephen,Fletcher ^[2] ; Reginald,Brys ^[2] ; Romain,Gosmini ^[1]

作者单位： Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France. ^[1] Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium. ^[2] Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom. ^[3]