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Impact of admixture and ancestry on eQTL analysis and GWAS colocalization in GTEx.

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第一作者： Nicole R,Gay

第一单位： Department of Genetics, Stanford University, Stanford, CA, USA.

作者： Nicole R,Gay ^[1] ; Michael,Gloudemans ^[2] ; Margaret L,Antonio ^[2] ; Nathan S,Abell ^[1] ; Brunilda,Balliu ^[3] ; YoSon,Park ^[4] ; Alicia R,Martin ^[5] ; Shaila,Musharoff ^[1] ; Abhiram S,Rao ^[6] ; François,Aguet ^[7] ; Alvaro N,Barbeira ^[8] ; Rodrigo,Bonazzola ^[8] ; Farhad,Hormozdiari ^[9] ; GTEx Consortium ^[7] ; Kristin G,Ardlie ^[10] ; Christopher D,Brown ^[8] ; Hae Kyung,Im ^[11] ; Tuuli,Lappalainen ^[12] ; Xiaoquan,Wen ^[13] ; Stephen B,Montgomery

作者单位： Department of Genetics, Stanford University, Stanford, CA, USA. ^[1] Biomedical Informatics, Stanford University, Stanford, CA, USA. ^[2] Department of Biomathematics, University of California, Los Angeles, Los Angeles, CA, USA. ^[3] Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[4] Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.;Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA. ^[5] Department of Bioengineering, Stanford University, Stanford, CA, USA. ^[6] The Broad Institute of MIT and Harvard, Cambridge, MA, USA. ^[7] Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL, USA. ^[8] The Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. ^[9] Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[10] New York Genome Center, New York, NY, USA.;Department of Systems Biology, Columbia University, New York, NY, USA. ^[11] Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA. ^[12] Department of Genetics, Stanford University, Stanford, CA, USA. smontgom@stanford.edu.;Department of Pathology, Stanford University, Stanford, CA, USA. smontgom@stanford.edu. ^[13]

关键词 Admixture Colocalization GTEx Gene expression Local ancestry Population structure eQTL

医学主题词基因表达(Gene Expression);基因组, 人(Genome, Human);全基因组关联研究(Genome-Wide Association Study);基因型(Genotype);人类(Humans);数量性状基因座位(Quantitative Trait Loci)

DOI 10.1186/s13059-020-02113-0

PMID 32912333

发布时间 2024-03-30

基金项目

U01HG009431/NH/NIH HHS/United States U01 HG009431/HG/NHGRI NIH HHS/United States U01HG009080/NH/NIH HHS/United States R01HG008150/NH/NIH HHS/United States R01HG010067/HG/NHGRI NIH HHS/United States T32 HG000044/HG/NHGRI NIH HHS/United States K99 MH117229/MH/NIMH NIH HHS/United States R01HL142015/NH/NIH HHS/United States R00 MH117229/MH/NIMH NIH HHS/United States P30 DK020595/DK/NIDDK NIH HHS/United States 5T32HG000044-22/HG/NHGRI NIH HHS/United States R01 HG010067/HG/NHGRI NIH HHS/United States

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